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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN2
All Species:
21.52
Human Site:
T481
Identified Species:
33.81
UniProt:
Q9H0D6
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0D6
NP_036387.2
950
108582
T481
I
S
P
N
T
S
F
T
S
D
G
S
P
S
P
Chimpanzee
Pan troglodytes
XP_514546
950
108522
T481
I
S
P
N
T
S
F
T
S
D
G
S
P
S
P
Rhesus Macaque
Macaca mulatta
XP_001094734
961
109718
T481
I
S
P
N
T
S
F
T
S
D
G
S
P
S
P
Dog
Lupus familis
XP_534324
950
108331
T481
I
S
P
N
T
S
F
T
S
D
G
S
P
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBR1
951
108669
A481
I
S
P
N
T
S
F
A
S
D
G
S
P
S
P
Rat
Rattus norvegicus
NP_001102066
561
63850
L156
V
Q
S
Y
V
E
G
L
C
W
V
L
R
Y
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505862
950
108030
T481
A
S
P
N
T
S
F
T
S
D
G
S
P
S
P
Chicken
Gallus gallus
Q5ZIP4
949
108524
N480
S
S
P
N
T
S
L
N
S
D
G
S
P
S
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM71
908
103942
R469
A
A
L
R
N
R
K
R
T
S
D
M
A
N
L
Honey Bee
Apis mellifera
XP_392371
860
99367
T440
P
T
G
Q
F
A
P
T
R
I
G
E
H
I
K
Nematode Worm
Caenorhab. elegans
Q9U299
975
110109
K501
L
K
A
L
L
N
V
K
G
E
E
S
P
A
D
Sea Urchin
Strong. purpuratus
XP_795068
1073
120270
S472
A
A
D
A
M
R
A
S
F
K
G
G
E
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FQ03
1020
116807
V491
V
G
A
A
I
V
D
V
E
N
S
L
E
S
D
Baker's Yeast
Sacchar. cerevisiae
Q02792
1006
115915
A498
I
D
D
A
V
S
K
A
N
K
T
N
F
N
L
Red Bread Mold
Neurospora crassa
Q8WZX5
1072
118291
T523
N
G
A
E
S
T
E
T
P
A
E
T
A
A
A
Conservation
Percent
Protein Identity:
100
99.7
97.6
98
N.A.
96
56.2
N.A.
91.1
82.9
N.A.
N.A.
N.A.
51.2
54
50.5
52.5
Protein Similarity:
100
99.8
98
99
N.A.
97
57.6
N.A.
95.4
90.5
N.A.
N.A.
N.A.
63.2
66.5
63.7
63.4
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
93.3
80
N.A.
N.A.
N.A.
0
13.3
13.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
6.6
N.A.
93.3
80
N.A.
N.A.
N.A.
20
26.6
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.6
40.5
40.8
Protein Similarity:
N.A.
N.A.
N.A.
58
57.4
56.1
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
14
20
20
0
7
7
14
0
7
0
0
14
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
7
14
0
0
0
7
0
0
47
7
0
0
0
14
% D
% Glu:
0
0
0
7
0
7
7
0
7
7
14
7
14
0
0
% E
% Phe:
0
0
0
0
7
0
40
0
7
0
0
0
7
0
0
% F
% Gly:
0
14
7
0
0
0
7
0
7
0
60
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
40
0
0
0
7
0
0
0
0
7
0
0
0
7
0
% I
% Lys:
0
7
0
0
0
0
14
7
0
14
0
0
0
0
7
% K
% Leu:
7
0
7
7
7
0
7
7
0
0
0
14
0
0
14
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
7
0
0
47
7
7
0
7
7
7
0
7
0
14
0
% N
% Pro:
7
0
47
0
0
0
7
0
7
0
0
0
54
0
47
% P
% Gln:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
14
0
7
7
0
0
0
7
0
7
% R
% Ser:
7
47
7
0
7
54
0
7
47
7
7
54
0
54
0
% S
% Thr:
0
7
0
0
47
7
0
47
7
0
7
7
0
0
0
% T
% Val:
14
0
0
0
14
7
7
7
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _